Compounds that Impact Chronic Inflammation

Compounds that Impact Chronic Inflammation

“LET FOOD BY THY MEDICINE AND MEDICINE BY THY FOOD.”

Hippocrates, 450 BC In our first blog post in the NuGenea Knowledge (NGK) series, chronic inflammation’s potentially negative impact on your health was described.  In these next two blog posts we’re going to review the naturally occurring minerals and compounds that have a significant impact on the biomarkers that cause chronic inflammation and provide other health benefits. Dr. Marvin D. Hausman, MD thoroughly researched the products of NuGenea half of which are presented here along with the various ways in which they impact chronic inflammation and provide other health benefits.  Dr. Hausman found 84 peer reviewed research articles that confirmed the positive impact these compounds can have on inflammation. Alpha Lipoic Acid
  • Direct Antioxidant and Anti-Inflammatory Agent
  • Upregulates nuclear factorE2 (Nrf2)
  • Scientific studies suggest role in lowering blood sugar levels and reducing symptoms of diabetic peripheral neuropathy
N-acetyl cysteine (NAC)
  • Powerful free radical scavenger, especially oxygen radicals involved in uncontrolled inflammation
  • Powerful antioxidant
  • Reduced biomarkers thought to cause chronic inflammation:  TNF-a, NF-kB, IFN-y and IL-6
Zinc Picolinate
  • Antioxidant and Anti-Inflammatory
  • Modulates proinflammatory cytokines NF-kB, TNF-a and IL-1B
  • Increases gene expression of A20 and PPAR-a zinc proteins with anti-inflammatory properties
CoQ10
  • Antioxidant
  • Body produces naturally but decreases with age
  • Reduces proinflammatory cytokines TNF-a, IL-6 and MMP-9
  • CoQ10 supplementation has beneficial effects on glycemic control
Vitamin A
  • Necessary for normal differentiation of epithelial tissues, visual process, reproduction and innate and adaptive immune system
  • Decreased GSH is associated with executive function decline (cognitive)
  • Declines in GSH is potentially predictive of age-related decline
Glutathione (GSH)
  • Reduced levels of GSH are associated with increased susceptibility to infection and oxidative stress
  • Decreased GSH is associated with executive function decline (cognitive)
  • Declines in GSH is potentially predictive of age-related decline
  • Oral GSH supplementation improves insulin sensitivity in obese subjects with and without T2DM
Vitamin C
  • Critical to making skin, tendons, ligaments and blood vessels
  • Important for repairing and maintaining cartilage, bones and teeth, healing wounds and the formation of scar tissue
  • Aids in the absorption of iron
  • Significant antioxidant and anti-inflammatory compound
  • Protects indispensable molecules in the body:  proteins, lipids, carbs and nucleic acids
  • Prevents and treats respiratory and systemic infections by enhancing various immune cell functions
Vitamin D
  • Helps body absorb and retain calcium and phosphorus
  • Potential for reducing cancer cell growth, control infections and reduce inflammation
  • Immune cells in autoimmune diseases respond to the ameliorative effects of Vitamin DPotentially regulates cytokine production
Vitamin E; a-tocopherol
  • Group of fat-soluble vitamins that acts as an antioxidant
  • Blocks the release of inflammatory cytokines including IL-1, IL-6, TNF and chemokine IL-8
  • Upregulates ICAM1 on endothelium, IL-1B and NF-kB
Quercetin dihydrate
  • Powerful and abundant (in diet) antioxidant that combats free radical damage and inflammation
  • Febrile seizure (FS) study in animals showed that IL-10 is genetically associated with FS
  • Upregulates ICAM1 on endothelium, IL-1B and NF-kB
  • Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity.
  • Quercetin appears to affect many factors and signaling pathways involved in insulin resistance and the pathogenesis of type 2 diabetes.
Be on the look out for our next NuGenea Knowledge post that will provide the final set of compounds that can help you fight chronic inflammation. To receive the complete white paper published by Dr. Hausman, please sent an email request to Luke@ludg.usOur flagship product NuGenea will be available very soon.  NuGenea which means ‘New Life’ (in Greek)is scientifically formulated by a physician.  NuGenea’s 20 ingredients have been extensively researched and have a demonstrated impact reducing inflammation.  Affordable and effective, NuGenea has enteric coating for maximum absorption and non-GMO ingredients.  Send an email to Luke@ludg.us and request that you be the first to receive NuGenea. 



Medically Reviewed:
Marvin D. Hausman, MD



Written by:
Luke Fannon

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